Training the next generation of virologists
Biography Research Title: Analysis of Host Membrane-shaping Reticulon Proteins in HIV-1 Replication Research Summary: Justin Massey tested and confirmed a robust and specific interaction between the reticulon homology proteins (RHPs) and VPU (Jager et al., Nature, 2012). However, he has not observed a clear, reproducible phenotype of knockdown or overexpression of RHPs on the two …
Biography Research Title: Inhibition of the mTOR and MEK/ERK Pathways Arrests Growth of Human Anal Caner Tumorgrafts and Causes Regression of Recurrent Cancer Research Summary: Patrick’s project investigated the capability of the Human Papilloma Virus (HPV) to dysregulate cell signaling pathways which contribute to viral amplification and tumorigenesis. HPV is known to infect squamous epithelial …
Biography Research Title: Discerning the Significance of Stem Cells in Papillomavirus Infection Research Description: Human papillomaviruses (HPVs) are associated with 5% of human cancers. Ruben Moreno studies papillomavirus-induced pathogenesis in the Lambert laboratory. Recently, the first papillomavirus discovered to naturally infect laboratory mice was discovered, providing investigators the ability to make use of the power …
Biography Research Title: Cooperation between HPV and Cellular Factors in Head and Neck Squamous Cell Carcinoma Research Summary: Patrick studied the Human Papillomavirus (HPV), a small DNA virus that infects stratified squamous epithelia, which is found in sites such as the skin, tongue, and cervix. HPV is known to be the primary cause of cervical …
Biography Research Title: Regulation of the Latent-to-Lytic Switch of Epstein-Barr Virus by the Cellular Differentiation Factor BLIMP1 Research Summary: Cellular transcription factors involved in mediating differentiation in epithelial and B cells likely contribute to EBV reactivation out of latency into lytic replication. Trainee Jessica Reusch has been investigating the ability of the master regulator …
Biography Research Title: Visualizing Vesicular Stomatitis Virus (VSV) Infection Spread and Resulting Host Immune Responses in Vitro with a Dual Color Fluorescent Reporter System Research Summary: Although the molecular mechanisms by which host cells defend themselves against viral infection have been studied in great depth, and countermeasures viruses employ to suppress such defensive responses have …
Biography Research Title: Regulation of Effector and Memory T Cell Differentiation by Transcription Factor FoxO1 and Iĸ Bα Nuclear Export of NF-ĸB Research Summary: The generation of long-term immunity and the development of vaccines against many viral pathogens such as polio, smallpox, and the flu, are dependent on the number and quality of long-lived memory …
Biography Research Title: Development of Single-Cell Techniques to Investigate Heterogeneity in Virus-Cell Interactions Research Summary: Andrea Timm contributed to developing and applying a micro-well array technology and quantitative imaging to characterize the kinetics of virus-host interactions at the single cell level. To enable real-time tracking of vesicular stomatitis virus (VSV) infection and cellular response Andrea …
Biography Research Title: Comparative Analysis of Rhinovirus 2A Protease Cleavage of the Nuclear Pore Complex Research Summary: The Palmenberg laboratory studies picornaviruses and are currently focusing their research on picornaviral proteins that inhibit nucleocytoplasmic trafficking in cells during infection. Human Rhinoviruses (HRVs) of the Enterovirus genus in the Picornaviridae family encode a protease, 2A, to …
Biography Research Title: Cytosine Modification of the Epstein-Barr Viral Genome Affects Lytic Reactivation and Helps Enforce Latency Type Research Summary: Coral Wille examined how cytosine methylation and 5’-hydroxycytosine methylation of the EBV genome affected the ability of the two EBV immediate-early viral proteins, BZLF1 and BRLF1, to activate early lytic viral promoters. Coral showed that …